Fibrinogen γ′ chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathway
نویسندگان
چکیده
منابع مشابه
extrinsic and intrinsic coagulation pathway, fibrinogen serum level and platelet count in hiv positive patients.
infection with human immunodeficiency virus (hiv) is a progressive condition which may cause endothelial dysfunction and liver damage leading to coagulopathy. with adventure of highly active antiretroviral therapy (haart), life expectancy has prolonged in hiv positive patients but several acquired immunodeficiency syndrome (aids)-related conditions such as coagulopathies are responsible for ass...
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Earlier studies showed that HepG2 cells stably transfected with any one fibrinogen chain cDNA enhance the expression of the other two fibrinogen chains. In this report, a regulatory element “TGCTCTC” in the γ fibrinogen promoter region, -322 to -316, is identified which is involved in increased expression of γ chain in HepG2 cells that are transfected with Bβ fibrinogen cDNA. By electrophoretic...
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The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding. The present study thus examined the a...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2007
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2007.06825.x